(DOWNLOAD) "Plasma Concentration of Heat Shock Protein 27 and Risk of Cardiovascular Disease: A Prospective, Nested Case- Control Study (Lipids, Lipoproteins, And Cardiovascular Risk Factors) (Clinical Report)" by Clinical Chemistry ~ eBook PDF Kindle ePub Free
eBook details
- Title: Plasma Concentration of Heat Shock Protein 27 and Risk of Cardiovascular Disease: A Prospective, Nested Case- Control Study (Lipids, Lipoproteins, And Cardiovascular Risk Factors) (Clinical Report)
- Author : Clinical Chemistry
- Release Date : January 01, 2008
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 244 KB
Description
Heat shock proteins (HSPs) [13] are molecular chaperones that protect against stress stimuli including heat shock, oxidized LDL, mechanical stress, oxidants, and cytokine stimulation (1). Their primary function is to fulfill chaperoning activity: as new proteins are being produced by ribosomes, HSPs assist in correct folding of polypeptide chains into functional protein, and after a stress event, HSPs assist in refolding or degradation of damaged or denatured proteins (2). HSPs are divided into several families according to molecular weight, including the 110, 90, 70, 60, and 40 kDa families, the small HSPs such as HSP27, and the HSP10 family. HSPs have been implicated in the pathogenesis of several disease processes. In relation to atherosclerosis, HSPs from the HSP60 and HSP70 families have been most widely investigated (1, 2). Recently, however, cardiovascular attention has also focused on HSP27, which is known to have chaperoning activity, to inhibit F-actin polymerization, to protect against apoptosis, and to be involved in the presentation of oxidized proteins to the proteosome degradation machinery (3). Specifically, using atherosclerotic carotid endarterectomy samples and control endarteries, we demonstrated that HSP27 secretion correlates negatively with atherosclerotic plaque complexity by comparing the complicated vs noncomplicated adjacent area from the same specimen and control endarteries. We also reported reduced HSP27 plasma concentrations in atherosclerotic patients compared with healthy individuals (4). Park et al. (5) used the same strategy but examined the tissue compartment, and also reported that HSP27 expression is increased in the normal-appearing vessel adjacent to atherosclerotic plaque compared with both the plaque core area and the reference arteries. By contrast, however, they reported that HSP27 plasma concentration was increased in acute coronary syndrome patients compared with normal individuals.